Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development

Company: AbbVie
Location: South San Francisco
Posted on: March 14, 2026

Job Description:

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description AbbVie is looking for a Senior Scientist to join our Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, identify and implement new methods and techniques, and collaborate cross-functionally to advance our pipeline of novel in vivo CAR-T therapies. Responsibilities: Lead research efforts, design and execute in vitro studies (multi-color flow cytometry, ELISA, luciferase, ddPCR, etc.) and collaborate with in vivo pharmacology group for in vivo studies to advance lentiviral-based delivery platform development. Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production by leveraging internal capabilities and external CRO partnerships. Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T pipeline programs from early discovery through translational development. Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment. Work independently with minimal supervision while maintaining a high level of productivity, efficiency, and scientific rigor. Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN). Analyze and interpret multidisciplinary data to generate actionable conclusions, identify key risks, and guide future experimental directions. Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization. Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications. Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed. Mentor and support junior scientists within the team. Qualifications BS, MS, or PhD inimmunology, oncology, cell biology, molecular biology, biochemistry, or related field with typically 10 (BS), 8 (MS), or 0-3 (PhD)years of experience. Expertise in mammalian primary cell and cell line culture (primary T cells, PBMCs, whole blood, suspension and adherent cell lines), multi-color flow cytometry (panel design, acquisition, and analysis), and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required. Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is highly preferred. Experience with lentiviral vector design, production, and analytical characterization (e.g., titering, copy number analysis, transduction efficiency assessment) is highly preferred. Experience in evaluating vector biodistribution, transduction specificity, or safety-related parameters is a plus. Experience in CAR-T cell therapy and/or in vivo targeted delivery is a plus. Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput. Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment. Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation. Detail-oriented with a passion for delivering high-quality results. Why AbbVie? AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine. How to Apply: If you are passionate about advancing in vivo CAR-T therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Pittsburg , Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development, Science, Research & Development , South San Francisco, California